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Gap junction alpha-3 protein

Intramolecular
Cysteine 65 and cysteine 178
Cysteine 61 and cysteine 183
Cysteine 54 and cysteine 189
Cysteine 65 and cysteine 183
Cysteine 178 and cysteine 189
Cysteine 178 and cysteine 183
Cysteine 61 and cysteine 65
Cysteine 65 and cysteine 189
Cysteine 61 and cysteine 178
Cysteine 54 and cysteine 65
More...
Cysteine 54 and cysteine 61
Cysteine 61 and cysteine 189
Cysteine 54 and cysteine 178
Cysteine 183 and cysteine 189
Cysteine 54 and cysteine 183
A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 65 and 178.

Details

Redox score ?
84
PDB code
6mhq
Structure name
structure of connexin-46 intercellular gap junction channel at 3
Structure deposition date
2018-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
65
Residue number B
178
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 65 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 61 and 183.

Details

Redox score ?
83
PDB code
6mhq
Structure name
structure of connexin-46 intercellular gap junction channel at 3
Structure deposition date
2018-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
61
Residue number B
183
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 61 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 54 and 189.

Details

Redox score ?
81
PDB code
6mhq
Structure name
structure of connexin-46 intercellular gap junction channel at 3
Structure deposition date
2018-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
54
Residue number B
189
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 54 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 65 and 183.

Details

Redox score ?
77
PDB code
7jkc
Structure name
sheep connexin-46 at 1
Structure deposition date
2020-07-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
65
Residue number B
183
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 65 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 178 and 189.

Details

Redox score ?
75
PDB code
6mhq
Structure name
structure of connexin-46 intercellular gap junction channel at 3
Structure deposition date
2018-09-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
178
Residue number B
189
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 178 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 178 and 183.

Details

Redox score ?
72
PDB code
6mhq
Structure name
structure of connexin-46 intercellular gap junction channel at 3
Structure deposition date
2018-09-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
178
Residue number B
183
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 178 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 61 and 65.

Details

Redox score ?
71
PDB code
7jn0
Structure name
sheep connexin-46 at 2
Structure deposition date
2020-08-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
61
Residue number B
65
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 61 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 65 and 189.

Details

Redox score ?
67
PDB code
7jn0
Structure name
sheep connexin-46 at 2
Structure deposition date
2020-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
65
Residue number B
189
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 65 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 61 and 178.

Details

Redox score ?
67
PDB code
6mhq
Structure name
structure of connexin-46 intercellular gap junction channel at 3
Structure deposition date
2018-09-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
61
Residue number B
178
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 61 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 54 and 65.

Details

Redox score ?
66
PDB code
7jkc
Structure name
sheep connexin-46 at 1
Structure deposition date
2020-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
54
Residue number B
65
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 54 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 54 and 61.

Details

Redox score ?
62
PDB code
7jmd
Structure name
sheep connexin-46 at 2
Structure deposition date
2020-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
54
Residue number B
61
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 54 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 61 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 61 and 189.

Details

Redox score ?
61
PDB code
7jkc
Structure name
sheep connexin-46 at 1
Structure deposition date
2020-07-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
61
Residue number B
189
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 61 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 54 and 178. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
7jn1
Structure name
sheep connexin-46 at 2
Structure deposition date
2020-08-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
54
Residue number B
178
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 54 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 183 and 189. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7jn1
Structure name
sheep connexin-46 at 2
Structure deposition date
2020-08-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
183
Residue number B
189
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 183 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction alpha-3 protein between cysteines 54 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7jkc
Structure name
sheep connexin-46 at 1
Structure deposition date
2020-07-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TU17
Residue number A
54
Residue number B
183
Peptide name
Gap junction alpha-3 protein

Ligandability

Cysteine 54 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Gap junction alpha-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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