TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Intermolecular
Cysteine 41 and cysteine 509 of Ataxin-7
Cysteine 574 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L and cysteine 230 L
Cysteine 260 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L and cysteine 230 L
Intramolecular
Cysteine 305 and cysteine 306
8h7g K 41 L 509
A redox-regulated disulphide may form between cysteine 41 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L and cysteine 509 of Ataxin-7.
Details
Redox score ?
64
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide A name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Peptide B name
Ataxin-7
Peptide A accession
Q9Y6J9
Peptide B accession
O15265
Peptide A residue number
41
Peptide B residue number
509
Ligandability
Cysteine 41 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Cysteine 509 of Ataxin-7
8h7g H 574 K 230
A redox-regulated disulphide may form between cysteine 574 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L and cysteine 230 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
60
Peptide A name
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Peptide B name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Peptide A accession
O75529
Peptide B accession
Q9Y6J9
Peptide A residue number
574
Peptide B residue number
230
Ligandability
Cysteine 574 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Cysteine 230 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
8h7g H 260 K 230
A redox-regulated disulphide may form between cysteine 260 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L and cysteine 230 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
68
Peptide A name
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Peptide B name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Peptide A accession
O75529
Peptide B accession
Q9Y6J9
Peptide A residue number
260
Peptide B residue number
230
Ligandability
Cysteine 260 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Cysteine 230 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
8h7g K 305 K 306
A redox-regulated disulphide may form within TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L between cysteines 305 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
22
Peptide accession
Q9Y6J9
Residue number A
305
Residue number B
306
Peptide name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Ligandability
Cysteine 305 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Cysteine 306 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
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