ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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2'-5'-oligoadenylate synthase 3

Intramolecular
Cysteine 323 and cysteine 328
Cysteine 175 and cysteine 183
A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase 3 between cysteines 323 and 328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4s3n
Structure name
crystal structure of human oas3 domain i in complex with dsrna
Structure deposition date
2015-02-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
70
Peptide accession
Q9Y6K5
Residue number A
323
Residue number B
328
Peptide name
2'-5'-oligoadenylate synthase 3

Ligandability

Cysteine 323 of 2'-5'-oligoadenylate synthase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of 2'-5'-oligoadenylate synthase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase 3 between cysteines 175 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4s3n
Structure name
crystal structure of human oas3 domain i in complex with dsrna
Structure deposition date
2015-02-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
77
Peptide accession
Q9Y6K5
Residue number A
175
Residue number B
183
Peptide name
2'-5'-oligoadenylate synthase 3

Ligandability

Cysteine 175 of 2'-5'-oligoadenylate synthase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of 2'-5'-oligoadenylate synthase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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