a tool for identifying drug-targetable redox-active disulphides

Sulfide:quinone oxidoreductase, mitochondrial

Intramolecular

Cysteine 201 and cysteine 379 L

A redox-regulated disulphide may form within Sulfide:quinone oxidoreductase, mitochondrial between cysteines 201 and 379.

Details

Redox score ?

63

PDB code

Structure name

crystal structure of human sulfide quinone oxidoreductase in complex with coenzyme q (sulfite soaked)

Structure deposition date

2019-04-09

Thiol separation (Å)

5

Half-sphere exposure sum ?

83

Minimum pK_a ?

11

% buried

nan

Peptide accession

Residue number A

201

Residue number B

379

Peptide name

Sulfide:quinone oxidoreductase, mitochondrial

Ligandability

Cysteine 201 of Sulfide:quinone oxidoreductase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 379 of Sulfide:quinone oxidoreductase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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