ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Roundabout homolog 1

Intramolecular
Cysteine 283 and cysteine 330
Cysteine 89 and cysteine 147
Cysteine 372 and cysteine 428
Cysteine 191 and cysteine 240
Cysteine 476 and cysteine 525
A redox-regulated disulphide may form within Roundabout homolog 1 between cysteines 283 and 330.

Details

Redox score ?
85
PDB code
5ope
Structure name
robo1 ig1-4 crystals form 2
Structure deposition date
2017-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6N7
Residue number A
283
Residue number B
330
Peptide name
Roundabout homolog 1

Ligandability

Cysteine 283 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 1 between cysteines 89 and 147.

Details

Redox score ?
83
PDB code
5o5g
Structure name
robo1 ig1 to 4 crystal form 1
Structure deposition date
2017-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6N7
Residue number A
89
Residue number B
147
Peptide name
Roundabout homolog 1

Ligandability

Cysteine 89 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 1 between cysteines 372 and 428.

Details

Redox score ?
83
PDB code
5ope
Structure name
robo1 ig1-4 crystals form 2
Structure deposition date
2017-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6N7
Residue number A
372
Residue number B
428
Peptide name
Roundabout homolog 1

Ligandability

Cysteine 372 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 428 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 1 between cysteines 191 and 240.

Details

Redox score ?
82
PDB code
5ope
Structure name
robo1 ig1-4 crystals form 2
Structure deposition date
2017-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6N7
Residue number A
191
Residue number B
240
Peptide name
Roundabout homolog 1

Ligandability

Cysteine 191 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 1 between cysteines 476 and 525 (30 and 79 respectively in this structure).

Details

Redox score ?
81
PDB code
6a77
Structure name
crystal structure of the fifth immunoglobulin domain (ig5) of human robo1 in complex with the fab fragment of murine monoclonal antibody b5209b
Structure deposition date
2018-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6N7
Residue number A
476
Residue number B
525
Peptide name
Roundabout homolog 1

Ligandability

Cysteine 476 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 525 of Roundabout homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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