Inducible T-cell costimulator
Intramolecular
Cysteine 63 and cysteine 83
Cysteine 42 and cysteine 109
Cysteine 63 and cysteine 109
Cysteine 42 and cysteine 83
Cysteine 42 and cysteine 63
7joo C 63 C 83
A redox-regulated disulphide may form within Inducible T-cell costimulator between cysteines 63 and 83.
Details
Redox score ?
85
PDB code
7joo
Structure name
crystal structure of icos in complex with antibody stim003 and anti- kappa vhh domain
Structure deposition date
2020-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6W8
Residue number A
63
Residue number B
83
Peptide name
Inducible T-cell costimulator
Ligandability
Cysteine 63 of Inducible T-cell costimulator
Cysteine 83 of Inducible T-cell costimulator
6x4g A 42 A 109
A redox-regulated disulphide may form within Inducible T-cell costimulator between cysteines 42 and 109.
Details
Redox score ?
82
PDB code
6x4g
Structure name
crystal structure of icos in complex with icos-l and an anti icos-l vnar domain
Structure deposition date
2020-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6W8
Residue number A
42
Residue number B
109
Peptide name
Inducible T-cell costimulator
Ligandability
Cysteine 42 of Inducible T-cell costimulator
Cysteine 109 of Inducible T-cell costimulator
6x4g A 63 A 109
A redox-regulated disulphide may form within Inducible T-cell costimulator between cysteines 63 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6x4g
Structure name
crystal structure of icos in complex with icos-l and an anti icos-l vnar domain
Structure deposition date
2020-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6W8
Residue number A
63
Residue number B
109
Peptide name
Inducible T-cell costimulator
Ligandability
Cysteine 63 of Inducible T-cell costimulator
Cysteine 109 of Inducible T-cell costimulator
7joo C 42 C 83
A redox-regulated disulphide may form within Inducible T-cell costimulator between cysteines 42 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7joo
Structure name
crystal structure of icos in complex with antibody stim003 and anti- kappa vhh domain
Structure deposition date
2020-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6W8
Residue number A
42
Residue number B
83
Peptide name
Inducible T-cell costimulator
Ligandability
Cysteine 42 of Inducible T-cell costimulator
Cysteine 83 of Inducible T-cell costimulator
7joo C 42 C 63
A redox-regulated disulphide may form within Inducible T-cell costimulator between cysteines 42 and 63. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7joo
Structure name
crystal structure of icos in complex with antibody stim003 and anti- kappa vhh domain
Structure deposition date
2020-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6W8
Residue number A
42
Residue number B
63
Peptide name
Inducible T-cell costimulator
Ligandability
Cysteine 42 of Inducible T-cell costimulator
Cysteine 63 of Inducible T-cell costimulator
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