ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Bis(5'-adenosyl)-triphosphatase ENPP4

Intramolecular
Cysteine 254 and cysteine 287
Cysteine 394 and cysteine 401
A redox-regulated disulphide may form within Bis(5'-adenosyl)-triphosphatase ENPP4 between cysteines 254 and 287.

Details

Redox score ?
86
PDB code
4lr2
Structure name
crystal structure of human enpp4 (apo)
Structure deposition date
2013-07-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6X5
Residue number A
254
Residue number B
287
Peptide name
Bis(5'-adenosyl)-triphosphatase ENPP4

Ligandability

Cysteine 254 of Bis(5'-adenosyl)-triphosphatase ENPP4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 287 of Bis(5'-adenosyl)-triphosphatase ENPP4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bis(5'-adenosyl)-triphosphatase ENPP4 between cysteines 394 and 401.

Details

Redox score ?
85
PDB code
4lr2
Structure name
crystal structure of human enpp4 (apo)
Structure deposition date
2013-07-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y6X5
Residue number A
394
Residue number B
401
Peptide name
Bis(5'-adenosyl)-triphosphatase ENPP4

Ligandability

Cysteine 394 of Bis(5'-adenosyl)-triphosphatase ENPP4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 401 of Bis(5'-adenosyl)-triphosphatase ENPP4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: