ATPase MORC2
Intramolecular
Cysteine 499 and cysteine 525 L
Cysteine 499 and cysteine 536 L
Cysteine 502 and cysteine 525 L
Cysteine 499 and cysteine 502 L
Cysteine 502 and cysteine 536 L
Cysteine 525 and cysteine 536
Cysteine 269 and cysteine 270
5ofb B 499 B 525
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 499 and 525.
Details
Redox score ?
86
PDB code
5ofb
Structure name
crystal structure of human morc2 (residues 1-603) with spinal muscular atrophy mutation s87l
Structure deposition date
2017-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
25
Peptide accession
Q9Y6X9
Residue number A
499
Residue number B
525
Peptide name
ATPase MORC2
Ligandability
Cysteine 499 of ATPase MORC2
Cysteine 525 of ATPase MORC2
5ofa B 499 B 536
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 499 and 536.
Details
Redox score ?
83
PDB code
5ofa
Structure name
crystal structure of human morc2 (residues 1-603) with spinal muscular atrophy mutation t424r
Structure deposition date
2017-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
16
Peptide accession
Q9Y6X9
Residue number A
499
Residue number B
536
Peptide name
ATPase MORC2
Ligandability
Cysteine 499 of ATPase MORC2
Cysteine 536 of ATPase MORC2
5ofa B 502 B 525
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 502 and 525.
Details
Redox score ?
82
PDB code
5ofa
Structure name
crystal structure of human morc2 (residues 1-603) with spinal muscular atrophy mutation t424r
Structure deposition date
2017-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
21
Peptide accession
Q9Y6X9
Residue number A
502
Residue number B
525
Peptide name
ATPase MORC2
Ligandability
Cysteine 502 of ATPase MORC2
Cysteine 525 of ATPase MORC2
5of9 A 499 A 502
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 499 and 502.
Details
Redox score ?
81
PDB code
5of9
Structure name
crystal structure of human morc2 (residues 1-603)
Structure deposition date
2017-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
27
Peptide accession
Q9Y6X9
Residue number A
499
Residue number B
502
Peptide name
ATPase MORC2
Ligandability
Cysteine 499 of ATPase MORC2
Cysteine 502 of ATPase MORC2
5ofb A 502 A 536
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 502 and 536.
Details
Redox score ?
79
PDB code
5ofb
Structure name
crystal structure of human morc2 (residues 1-603) with spinal muscular atrophy mutation s87l
Structure deposition date
2017-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
10
Peptide accession
Q9Y6X9
Residue number A
502
Residue number B
536
Peptide name
ATPase MORC2
Ligandability
Cysteine 502 of ATPase MORC2
Cysteine 536 of ATPase MORC2
5of9 A 525 A 536
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 525 and 536.
Details
Redox score ?
79
PDB code
5of9
Structure name
crystal structure of human morc2 (residues 1-603)
Structure deposition date
2017-07-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
11
Peptide accession
Q9Y6X9
Residue number A
525
Residue number B
536
Peptide name
ATPase MORC2
Ligandability
Cysteine 525 of ATPase MORC2
Cysteine 536 of ATPase MORC2
5ofb B 269 B 270
A redox-regulated disulphide may form within ATPase MORC2 between cysteines 269 and 270. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
5ofb
Structure name
crystal structure of human morc2 (residues 1-603) with spinal muscular atrophy mutation s87l
Structure deposition date
2017-07-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
77
Peptide accession
Q9Y6X9
Residue number A
269
Residue number B
270
Peptide name
ATPase MORC2
Ligandability
Cysteine 269 of ATPase MORC2
Cysteine 270 of ATPase MORC2
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