ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calmodulin-binding transcription activator 1

Intramolecular
Cysteine 904 and cysteine 923
Cysteine 923 and cysteine 925
A redox-regulated disulphide may form within Calmodulin-binding transcription activator 1 between cysteines 904 and 923.

Details

Redox score ?
69
PDB code
2cxk
Structure name
crystal structure of the tig domain of human calmodulin- binding transcription activator 1 (camta1)
Structure deposition date
2005-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide accession
Q5VUE1
Residue number A
904
Residue number B
923
Peptide name
Calmodulin-binding transcription activator 1

Ligandability

Cysteine 904 of Calmodulin-binding transcription activator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 923 of Calmodulin-binding transcription activator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calmodulin-binding transcription activator 1 between cysteines 923 and 925. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2cxk
Structure name
crystal structure of the tig domain of human calmodulin- binding transcription activator 1 (camta1)
Structure deposition date
2005-06-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
78
Peptide accession
Q5VUE1
Residue number A
923
Residue number B
925
Peptide name
Calmodulin-binding transcription activator 1

Ligandability

Cysteine 923 of Calmodulin-binding transcription activator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 925 of Calmodulin-binding transcription activator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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