ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II antigen

Intramolecular
Cysteine 144 and cysteine 200
Cysteine 44 and cysteine 106
A redox-regulated disulphide may form within MHC class II antigen between cysteines 144 and 200 (115 and 171 respectively in this structure).

Details

Redox score ?
80
PDB code
7t6i
Structure name
crystal structure of hla-dp1 in complex with pp65 peptide in reverse orientation
Structure deposition date
2021-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
S6B6U4
Residue number A
144
Residue number B
200
Peptide name
MHC class II antigen

Ligandability

Cysteine 144 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen between cysteines 44 and 106 (15 and 77 respectively in this structure).

Details

Redox score ?
79
PDB code
7t6i
Structure name
crystal structure of hla-dp1 in complex with pp65 peptide in reverse orientation
Structure deposition date
2021-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
S6B6U4
Residue number A
44
Residue number B
106
Peptide name
MHC class II antigen

Ligandability

Cysteine 44 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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