ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IgG H chain

Intramolecular
Cysteine 171 and cysteine 227
Cysteine 41 and cysteine 115
A redox-regulated disulphide may form within IgG H chain between cysteines 171 and 227 (148 and 204 respectively in this structure).

Details

Redox score ?
80
PDB code
5wkz
Structure name
vh1-69 germline antibody predicted from cr6261
Structure deposition date
2017-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
S6BAM6
Residue number A
171
Residue number B
227
Peptide name
IgG H chain

Ligandability

Cysteine 171 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IgG H chain between cysteines 41 and 115 (22 and 96 respectively in this structure).

Details

Redox score ?
79
PDB code
5wkz
Structure name
vh1-69 germline antibody predicted from cr6261
Structure deposition date
2017-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
S6BAM6
Residue number A
41
Residue number B
115
Peptide name
IgG H chain

Ligandability

Cysteine 41 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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