ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IgG H chain

Intramolecular
Cysteine 41 and cysteine 115
Cysteine 170 and cysteine 226
A redox-regulated disulphide may form within IgG H chain between cysteines 41 and 115 (22 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
5whj
Structure name
crystal structure of fab fragment of anti-fcrn antibody dx-2507
Structure deposition date
2017-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
S6BAN1
Residue number A
41
Residue number B
115
Peptide name
IgG H chain

Ligandability

Cysteine 41 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IgG H chain between cysteines 170 and 226 (143 and 199 respectively in this structure).

Details

Redox score ?
79
PDB code
5whj
Structure name
crystal structure of fab fragment of anti-fcrn antibody dx-2507
Structure deposition date
2017-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
S6BAN1
Residue number A
170
Residue number B
226
Peptide name
IgG H chain

Ligandability

Cysteine 170 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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