ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II histocompatibility antigen DQ beta chain

Intramolecular
Cysteine 149 and cysteine 205
Cysteine 47 and cysteine 111
A redox-regulated disulphide may form within HLA class II histocompatibility antigen DQ beta chain between cysteines 149 and 205 (117 and 173 respectively in this structure).

Details

Redox score ?
81
PDB code
2nna
Structure name
structure of the mhc class ii molecule hla-dq8 bound with a deamidated gluten peptide
Structure deposition date
2006-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5Y7F6
Residue number A
149
Residue number B
205
Peptide name
HLA class II histocompatibility antigen DQ beta chain

Ligandability

Cysteine 149 of HLA class II histocompatibility antigen DQ beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of HLA class II histocompatibility antigen DQ beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen DQ beta chain between cysteines 47 and 111 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
2nna
Structure name
structure of the mhc class ii molecule hla-dq8 bound with a deamidated gluten peptide
Structure deposition date
2006-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5Y7F6
Residue number A
47
Residue number B
111
Peptide name
HLA class II histocompatibility antigen DQ beta chain

Ligandability

Cysteine 47 of HLA class II histocompatibility antigen DQ beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of HLA class II histocompatibility antigen DQ beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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