ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Intramolecular
Cysteine 41 and cysteine 115
Cysteine 166 and cysteine 221
A redox-regulated disulphide may form within Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain between cysteines 41 and 115 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
1rih
Structure name
crystal structure of fab 14f7, a unique anti-tumor antibody specific for n-glycolyl gm3
Structure deposition date
2003-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
U5LP42
Residue number A
41
Residue number B
115
Peptide name
Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Ligandability

Cysteine 41 of Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain between cysteines 166 and 221 (140 and 195 respectively in this structure).

Details

Redox score ?
79
PDB code
1rih
Structure name
crystal structure of fab 14f7, a unique anti-tumor antibody specific for n-glycolyl gm3
Structure deposition date
2003-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
U5LP42
Residue number A
166
Residue number B
221
Peptide name
Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Ligandability

Cysteine 166 of Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: