ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Intramolecular
Cysteine 69 and cysteine 96
A redox-regulated disulphide may form within Nicotinate-nucleotide pyrophosphorylase [carboxylating] between cysteines 69 and 96.

Details

Redox score ?
73
PDB code
5ayz
Structure name
crystal structure of human quinolinate phosphoribosyltransferase in complex with the product nicotinate mononucleotide
Structure deposition date
2015-09-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
5
% buried
63
Peptide accession
V9HWJ5
Residue number A
69
Residue number B
96
Peptide name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Ligandability

Cysteine 69 of Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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